Work Package 8:
Clinical Studies

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After we have developed a prototype system to provision genetically matched blood to patients we will need to show that it can work and that it will improve clinical outcomes for patients.

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We anticipate performing a feasibility study in a small number of hospitals to show that the new system is operationally possible.

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Following this, we will perform a randomised trial to assess whether extended red cell matching improves treatment outcomes relative to the present system.

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We will need to obtain funding and formal ethical approval for these studies.

If the randomised trial shows a benefit large enough to justify the cost of a new system, then with NHSBT we will seek to initiate the changes required to update the standard of care in the NHS.